|
KMID : 0385920170280030255
|
|
Journal of the Korean Society of Emergency Medicine
2017 Volume.28 No. 3 p.255 ~ p.262
|
|
|
Efficacy of Red Cell Distribution Width as Prognostic Factor for Sepsis-3 Patients in Emergency Department
|
|
Lee Sung
Hong Dae-Young
Kim Jong-Won
Kim Sin-Young
Park Sang-O
Lee Kyeong-Ryong
Baek Kwang-Je
Kim Jin-Young
|
|
|
Abstract
|
|
|
Purpose: Red cell distribution width (RDW) was introduced as a new biomarker for the prognosis of sepsis patients. In addition, the definition of sepsis has changed recently to sepsis-3 criteria. The aim of this study was to compare the efficacy of RDW as a prognostic factor for sepsis-3 patients in the emergency department.
Method: We conducted a retrospective study of patients who were suspected of having sepsis between October, 2015 and April, 2016. The demographic data, comorbidities, blood test results, including RDW, lactate, C-reactive protein, and procalcitonin at admission, as well as the Mortality in Emergency Department Sepsis score were compared between the 30-day survivors and nonsurvivors. Analysis compared the areas under the receiver operator characteristic curves for 30-day mortality. Multivariate Cox proportional hazards regression analysis was performed to determine the risk factors for mortality.
Results: A total of 222 patients were included. The mean age was 75, 51.8% of the patient population was male, and the overall mortality rate was 16.7%. The non-survival group had higher RDW levels than the survivor group (14.5% vs 13.4%). The area under the receiver operating characteristic curve of RDW to predict mortality was 0.724. In a Cox proportional hazards analysis, RDW had 1.292 hazard ratio. Setting the RDW cutoff value to 14.3, we found that sensitivity and specificity of predicting mortality was 75.1% and 70.3%, respectively.
Conclusion: It may be possible to use RDW to predict mortality in sepsis-3 patients.
|
|
|
KEYWORD
|
|
|
Sepsis, Red blood cell, Prognosis, Mortality, Emergency departments
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|